Does Sulfamethoxazole And Trimethoprim Interact with Metformin?
Sulfamethoxazole And Trimethoprim and Metformin have a moderate drug interaction according to U.S. FDA drug labeling data. Cases of interactions reported with metformin, an OCT2 substrate. Trimethoprim inhibits OCT2 transporter. The mechanism involves oct2 transporter inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Sulfamethoxazole And Trimethoprim Class
- Sulfonamide Antimicrobial
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Sulfamethoxazole And Trimethoprim and Metformin occurs because oct2 transporter inhibition. Clinically, this means cases of interactions reported with metformin, an oct2 substrate. trimethoprim inhibits oct2 transporter. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Sulfamethoxazole And Trimethoprim and your doctor is considering prescribing Metformin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider