Does Abacavir Sulfate Dolutegravir Sodium Lamivudine Interact with Metformin?
CDI records a contraindicated classification for Abacavir Sulfate Dolutegravir Sodium Lamivudine and Metformin. The stored summary is: Dolutegravir inhibits OCT2 and potentially MATE1, may increase plasma concentrations of metformin. The mechanism involves inhibition of organic cation transporter (oct)2 and multidrug and toxin extrusion transporter (mate)1. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Abacavir Sulfate Dolutegravir Sodium Lamivudine Class
- Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Inhibition of organic cation transporter (OCT)2 and multidrug and toxin extrusion transporter (MATE)1
What To Tell Your Doctor or Pharmacist
If you are taking Abacavir Sulfate Dolutegravir Sodium Lamivudine and your doctor is considering prescribing Metformin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider