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Does Tafenoquine Succinate Interact with Dofetilide?

Tafenoquine Succinate and Dofetilide have a moderate drug interaction according to U.S. FDA drug labeling data. Tafenoquine may increase dofetilide concentrations via OCT2/MATE transporter inhibition, raising toxicity risk. Monitor for toxicities and consider dosage reduction. The mechanism involves inhibition of organic cation transporter-2 (oct2) and multidrug and toxin extrusion (mate) transporters. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity: Moderate
Dofetilide Class: Antiarrhythmic
Management: Monitor for effects
Data Source: U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Tafenoquine Succinate and Dofetilide occurs because inhibition of organic cation transporter-2 (oct2) and multidrug and toxin extrusion (mate) transporters. Clinically, this means tafenoquine may increase dofetilide concentrations via oct2/mate transporter inhibition, raising toxicity risk. monitor for toxicities and consider dosage reduction. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.

What To Tell Your Doctor or Pharmacist

If you are taking Tafenoquine Succinate and your doctor is considering prescribing Dofetilide (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Ask whether any dosage adjustments are needed
Never stop or change either medication without first consulting your healthcare provider

💊 Tafenoquine Succinate(Krintafel)+💊 Dofetilide(Tikosyn)

Severity & Interaction Details

🟡

moderate

Be aware — moderate interaction

Documented interaction with manageable risk. May require dose adjustment or monitoring.

Severity scale

MinorContra

On record

Yes

Drug A class

—

Drug B class

Antiarrhythmic

Source

NLP:tafenoquine succinate

What this means in plain English

Tafenoquine may increase dofetilide concentrations via OCT2/MATE transporter inhibition, raising toxicity risk. Monitor for toxicities and consider dosage reduction.

About Tafenoquine Succinate and Dofetilide

Dofetilide is an Antiarrhythmic. You may recognize them by the brand names Krintafel and Tikosyn. Both medications are taken by mouth. Dofetilide additionally carries an FDA boxed warning, the FDA's strongest safety alert.

What the FDA label says

"Inhibition of organic cation transporter-2 (OCT2) and multidrug and toxin extrusion (MATE) transporters"

📖 Source: NLP:tafenoquine succinate

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.