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Does Abacavir Sulfate Dolutegravir Sodium Lamivudine Interact with Dofetilide?

Abacavir Sulfate Dolutegravir Sodium Lamivudine and Dofetilide have a contraindicated drug interaction according to U.S. FDA drug labeling data. Dolutegravir inhibits OCT2, may increase plasma concentrations of dofetilide, a drug eliminated via OCT2. The mechanism involves inhibition of organic cation transporter (oct)2. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Abacavir Sulfate Dolutegravir Sodium Lamivudine Class
Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor
Dofetilide Class
Antiarrhythmic
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Abacavir Sulfate Dolutegravir Sodium Lamivudine and Dofetilide occurs because inhibition of organic cation transporter (oct)2. Clinically, this means dolutegravir inhibits oct2, may increase plasma concentrations of dofetilide, a drug eliminated via oct2. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Abacavir Sulfate Dolutegravir Sodium Lamivudine and your doctor is considering prescribing Dofetilide (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Abacavir Sulfate Dolutegravir Sodium Lamivudine(Triumeq)+💊 Dofetilide(Tikosyn)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor
Drug B class
Antiarrhythmic
Source
NLP:abacavir sulfate, dolutegravir sodium, lamivudine

What this means in plain English

Dolutegravir inhibits OCT2, may increase plasma concentrations of dofetilide, a drug eliminated via OCT2.

About Abacavir Sulfate Dolutegravir Sodium Lamivudine and Dofetilide

Abacavir Sulfate Dolutegravir Sodium Lamivudine is a Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor, while Dofetilide is an Antiarrhythmic. You may recognize them by the brand names Triumeq and Tikosyn. Both medications are taken by mouth. Both Abacavir Sulfate Dolutegravir Sodium Lamivudine and Dofetilide carry an FDA boxed warning — the agency's most serious safety designation.

What the FDA label says

"Inhibition of organic cation transporter (OCT)2"

📖 Source: NLP:abacavir sulfate, dolutegravir sodium, lamivudine

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.