Does Tecovirimat Monohydrate Interact with Smallpox Vaccine Vaccinia Virus?
Tecovirimat Monohydrate and Smallpox Vaccine Vaccinia Virus have a unknown drug interaction according to U.S. FDA drug labeling data. Co-administration of TPOXX with live smallpox vaccine may reduce immune response to the vaccine. Clinical impact on vaccine efficacy is unknown. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Unknown
- Tecovirimat Monohydrate Class
- Orthopoxvirus VP37 Envelope Wrapping Protein Inhibitor
- Management
- Consult your pharmacist
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Tecovirimat Monohydrate and your doctor is considering prescribing Smallpox Vaccine Vaccinia Virus (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider