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Does Telmisartan Amlodipine And Indapamide Interact with Digoxin?

Telmisartan Amlodipine And Indapamide and Digoxin have a major drug interaction according to U.S. FDA drug labeling data. Telmisartan co-administration increases digoxin peak plasma concentration (49%) and trough concentration (20%), requiring therapeutic monitoring. The mechanism involves increased digoxin plasma concentrations. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Telmisartan Amlodipine And Indapamide Class
Thiazide-like Diuretic
Digoxin Class
Cardiac Glycoside
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Telmisartan Amlodipine And Indapamide and Digoxin occurs because increased digoxin plasma concentrations. Clinically, this means telmisartan co-administration increases digoxin peak plasma concentration (49%) and trough concentration (20%), requiring therapeutic monitoring. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Telmisartan Amlodipine And Indapamide and your doctor is considering prescribing Digoxin (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Telmisartan Amlodipine And Indapamide(Widaplik)+💊 Digoxin(Digoxin)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Thiazide-like Diuretic
Drug B class
Cardiac Glycoside
Source
NLP:telmisartan, amlodipine and indapamide

What this means in plain English

Telmisartan co-administration increases digoxin peak plasma concentration (49%) and trough concentration (20%), requiring therapeutic monitoring.

What the FDA label says

"Increased digoxin plasma concentrations"

📖 Source: NLP:telmisartan, amlodipine and indapamide

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.