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Does Telmisartan And Hydrochlorothiazide Interact with Mao Inhibitors?

Telmisartan And Hydrochlorothiazide and Mao Inhibitors have a major drug interaction according to U.S. FDA drug labeling data. COX-2 inhibitors may result in deterioration of renal function and reduce the diuretic, natriuretic, and antihypertensive effects similar to NSAIDs. The mechanism involves cox-2 inhibitors antagonize effects of arbs and diuretics; renal impairment risk in susceptible patients. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Telmisartan And Hydrochlorothiazide Class
Angiotensin 2 Receptor Blocker
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Telmisartan And Hydrochlorothiazide and Mao Inhibitors occurs because cox-2 inhibitors antagonize effects of arbs and diuretics; renal impairment risk in susceptible patients. Clinically, this means cox-2 inhibitors may result in deterioration of renal function and reduce the diuretic, natriuretic, and antihypertensive effects similar to nsaids. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Telmisartan And Hydrochlorothiazide and your doctor is considering prescribing Mao Inhibitors (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Telmisartan And Hydrochlorothiazide(Telmisartan And Hydrochlorothiazide)+💊 Mao Inhibitors

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Angiotensin 2 Receptor Blocker
Drug B class
—
Source
NLP:telmisartan and hydrochlorothiazide

What this means in plain English

COX-2 inhibitors may result in deterioration of renal function and reduce the diuretic, natriuretic, and antihypertensive effects similar to NSAIDs.

What the FDA label says

"COX-2 inhibitors antagonize effects of ARBs and diuretics; renal impairment risk in susceptible patients"

📖 Source: NLP:telmisartan and hydrochlorothiazide

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.