Does Tenofovir Disoproxil Fumarate Interact with Valganciclovir?
Tenofovir Disoproxil Fumarate and Valganciclovir have a moderate drug interaction according to U.S. FDA drug labeling data. Coadministration may increase tenofovir concentrations due to active tubular secretion competition. Monitor for evidence of tenofovir toxicity. The mechanism involves competition for renal tubular secretion. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Valganciclovir Class
- Cytomegalovirus Nucleoside Analog DNA Polymerase Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Tenofovir Disoproxil Fumarate and Valganciclovir occurs because competition for renal tubular secretion. Clinically, this means coadministration may increase tenofovir concentrations due to active tubular secretion competition. monitor for evidence of tenofovir toxicity. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Tenofovir Disoproxil Fumarate and your doctor is considering prescribing Valganciclovir (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider