Does Thiothixene Interact with Carbamazepine?
CDI records a moderate classification for Thiothixene and Carbamazepine. The stored summary is: Significantly increases clearance of thiothixene, potentially reducing its effectiveness. Patients should be monitored for signs of reduced thiothixene efficacy. The mechanism involves hepatic microsomal enzyme induction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Thiothixene Class
- Typical Antipsychotic
- Carbamazepine Class
- Mood Stabilizer
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Hepatic microsomal enzyme induction
What To Tell Your Doctor or Pharmacist
If you are taking Thiothixene and your doctor is considering prescribing Carbamazepine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider