Does Tobramycin Interact with Urea?
CDI records a contraindicated classification for Tobramycin and Urea. The stored summary is: Concomitant administration not recommended due to possible enhancement of aminoglycoside toxicity by altering serum and tissue concentrations. The mechanism involves alteration of aminoglycoside concentrations in serum and tissue. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Tobramycin Class
- Aminoglycoside Antibacterial
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Alteration of aminoglycoside concentrations in serum and tissue
What To Tell Your Doctor or Pharmacist
If you are taking Tobramycin and your doctor is considering prescribing Urea (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider