Does Tobramycin Solution Interact with Furosemide?
CDI records a major classification for Tobramycin Solution and Furosemide. The stored summary is: Concomitant administration can enhance aminoglycoside toxicity by altering aminoglycoside concentrations in serum and tissue. The mechanism involves enhancement of aminoglycoside toxicity through altered serum and tissue concentrations. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Tobramycin Solution Class
- Aminoglycoside Antibacterial
- Furosemide Class
- Loop Diuretic
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Enhancement of aminoglycoside toxicity through altered serum and tissue concentrations
What To Tell Your Doctor or Pharmacist
If you are taking Tobramycin Solution and your doctor is considering prescribing Furosemide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider