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Does Tobramycin Solution Interact with Ethacrynic Acid?

Tobramycin Solution and Ethacrynic Acid have a major drug interaction according to U.S. FDA drug labeling data. Concomitant administration can enhance aminoglycoside toxicity by altering aminoglycoside concentrations in serum and tissue. The mechanism involves enhancement of aminoglycoside toxicity through altered serum and tissue concentrations. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Tobramycin Solution Class
Aminoglycoside Antibacterial
Ethacrynic Acid Class
Loop Diuretic
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Tobramycin Solution and Ethacrynic Acid occurs because enhancement of aminoglycoside toxicity through altered serum and tissue concentrations. Clinically, this means concomitant administration can enhance aminoglycoside toxicity by altering aminoglycoside concentrations in serum and tissue. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Tobramycin Solution and your doctor is considering prescribing Ethacrynic Acid (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Tobramycin Solution(Tobramycin)+💊 Ethacrynic Acid(Edecrin)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Aminoglycoside Antibacterial
Drug B class
Loop Diuretic
Source
NLP:tobramycin solution

What this means in plain English

Concomitant administration can enhance aminoglycoside toxicity by altering aminoglycoside concentrations in serum and tissue.

About Tobramycin Solution and Ethacrynic Acid

Tobramycin Solution is an Aminoglycoside Antibacterial, while Ethacrynic Acid is a Loop Diuretic. Ethacrynic Acid is also sold under the brand name Edecrin. Tobramycin Solution is inhaled, whereas Ethacrynic Acid is taken by mouth.

What the FDA label says

"Enhancement of aminoglycoside toxicity through altered serum and tissue concentrations"

📖 Source: NLP:tobramycin solution

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.