Does Tocilizumab Interact with Omeprazole?
CDI records a moderate classification for Tocilizumab and Omeprazole. The stored summary is: Tocilizumab may decrease omeprazole exposure by up to 28% due to increased CYP2C19 and CYP3A4 metabolism. Therapeutic monitoring recommended. The mechanism involves inhibition of il-6 signaling restores cyp450 activities, increasing metabolism of cyp substrates. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
Evidence status
A current label comparison is not yet available for this record. The summary and severity are stored CDI information; they have not been independently validated on this page against the exact product label.
Confirm the medicine, formulation, route, and applicable warning with your pharmacist or prescriber. Independent clinical review has not been recorded.
- Stored CDI classification
- Moderate
- Tocilizumab Class
- Interleukin-6 Receptor Antagonist
- Omeprazole Class
- Proton Pump Inhibitor
- Management
- Confirm exact products with your pharmacist
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Inhibition of IL-6 signaling restores CYP450 activities, increasing metabolism of CYP substrates
What To Tell Your Doctor or Pharmacist
If you are taking Tocilizumab and your doctor is considering prescribing Omeprazole (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider