Does Tolcapone Interact with Desipramine?
Tolcapone and Desipramine have a minor drug interaction according to U.S. FDA drug labeling data. In vitro and in vivo studies showed tolcapone did not change desipramine pharmacokinetics or affect hemodynamic parameters when given with levodopa/carbidopa. The mechanism involves cyp450 2d6. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Minor
- Tolcapone Class
- Catechol-O-Methyltransferase Inhibitor
- Management
- Generally manageable
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Tolcapone and Desipramine occurs because cyp450 2d6. Clinically, this means in vitro and in vivo studies showed tolcapone did not change desipramine pharmacokinetics or affect hemodynamic parameters when given with levodopa/carbidopa. This is classified as a minor interaction with generally low clinical significance, though your healthcare provider should still be informed that you are taking both medications.
What To Tell Your Doctor or Pharmacist
If you are taking Tolcapone and your doctor is considering prescribing Desipramine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider