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Does Tretinoin Interact with Acetazolamide?

Tretinoin and Acetazolamide have a contraindicated drug interaction according to U.S. FDA drug labeling data. Should not be administered concomitantly due to possibility of augmented phototoxicity as sulfonamides are known photosensitizers. The mechanism involves augmented phototoxicity. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Tretinoin Class
Retinoid
Acetazolamide Class
Carbonic Anhydrase Inhibitor
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Tretinoin and Acetazolamide occurs because augmented phototoxicity. Clinically, this means should not be administered concomitantly due to possibility of augmented phototoxicity as sulfonamides are known photosensitizers. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Tretinoin and your doctor is considering prescribing Acetazolamide (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Tretinoin(Retin-A)+💊 Acetazolamide

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Retinoid
Drug B class
Carbonic Anhydrase Inhibitor
Source
NLP:tretinoin

What this means in plain English

Should not be administered concomitantly due to possibility of augmented phototoxicity as sulfonamides are known photosensitizers.

About Tretinoin and Acetazolamide

Tretinoin is a Retinoid, while Acetazolamide is a Carbonic Anhydrase Inhibitor. Tretinoin is also sold under the brand name Retin-A. Tretinoin is applied to the skin, whereas Acetazolamide is given by intravenous (IV) infusion. Tretinoin additionally carries an FDA boxed warning, the FDA's strongest safety alert.

What the FDA label says

"Augmented phototoxicity"

📖 Source: NLP:tretinoin

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.