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Does Triamterene And Hydrochlorothiazide Interact with Indomethacin?

CDI records a major classification for Triamterene And Hydrochlorothiazide and Indomethacin. The stored summary is: Acute renal failure reported in patients receiving indomethacin with triamterene and hydrochlorothiazide formulations. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.

Severity
Major
Triamterene And Hydrochlorothiazide Class
Thiazide Diuretic
Indomethacin Class
Nonsteroidal Anti-inflammatory Drug
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Triamterene And Hydrochlorothiazide and your doctor is considering prescribing Indomethacin (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Triamterene And Hydrochlorothiazide(Dyazide)+💊 Indomethacin(Tivorbex)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Thiazide Diuretic
Drug B class
Nonsteroidal Anti-inflammatory Drug
Source
NLP:triamterene and hydrochlorothiazide

What this means in plain English

Acute renal failure reported in patients receiving indomethacin with triamterene and hydrochlorothiazide formulations.

About Triamterene And Hydrochlorothiazide and Indomethacin

Triamterene And Hydrochlorothiazide is a Thiazide Diuretic, while Indomethacin is a Nonsteroidal Anti-inflammatory Drug. You may recognize them by the brand names Dyazide and Tivorbex. Both Triamterene And Hydrochlorothiazide and Indomethacin carry an FDA boxed warning — the agency's most serious safety designation.

Source and Limitations

This record was produced by automated extraction from drug-label information, including AI processing. The summary and mechanism are not verbatim FDA quotations. The drug profiles below may describe different formulations from the source label. Confirm the exact product and route with your pharmacist. This page does not establish independent clinical review.

📖 Source: NLP:triamterene and hydrochlorothiazide

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How this information is prepared: CDI uses automated extraction, including AI, to summarize drug labeling from openFDA and includes separately identified curated-reference records. RxNorm helps identify medications; it does not verify interaction claims. Extracted summaries and CDI severity classifications can contain errors and are not verbatim FDA statements or independent clinical review. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.

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