Does Valproic Acid Interact with Sodium Phenylacetate And Sodium Benzoate?
CDI records a major classification for Valproic Acid and Sodium Phenylacetate And Sodium Benzoate. The stored summary is: May exacerbate urea cycle disorder and antagonize efficacy by inhibiting N-acetylglutamate synthesis, a cofactor for carbamyl phosphate synthetase. The mechanism involves inhibition of n-acetylglutamate synthesis. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Valproic Acid Class
- Anti-epileptic Agent
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Inhibition of N-acetylglutamate synthesis
What To Tell Your Doctor or Pharmacist
If you are taking Valproic Acid and your doctor is considering prescribing Sodium Phenylacetate And Sodium Benzoate (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider