Nitrates has 23 known drug interactions based on U.S. FDA drug labeling data. Of these, 8 are contraindicated combinations that should be avoided entirely. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Avanafil, Macitentan And Tadalafil, Riociguat. Patients taking Nitrates should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 23
- Contraindicated
- 8
- Major
- 3
- Moderate
- 9
- Minor
- 3
Contraindicated (8)
- Nitrates + Avanafil— Avanafil is contraindicated with organic nitrates. Avanafil potentiates the hypotensive effect of nitrates, which can be…
- Nitrates + Macitentan And Tadalafil— Administration of nitrates within 48 hours after the last dose of OPSYNVI is contraindicated.
- Nitrates + Riociguat— Co-administration with nitrates is contraindicated because of hypotension.
- Nitrates + Sildenafil— Administration of sildenafil with nitrates is contraindicated. Sildenafil potentiates the hypotensive effects of nitrate…
- Nitrates + Sildenafil Citrate— Administration of sildenafil with nitrates is contraindicated. Sildenafil potentiates the hypotensive effects of nitrate…
- Nitrates + Tadalafil— Administration of tadalafil to patients using any form of organic nitrate is contraindicated. Tadalafil potentiates the …
- Nitrates + Vardenafil— Concomitant use is contraindicated. Vardenafil potentiates blood pressure lowering effects and increases heart rate when…
- Nitrates + Vardenafil Hydrochloride— Concomitant use of vardenafil hydrochloride and nitrates is contraindicated. Vardenafil potentiates the blood pressure l…
Major (3)
- Nitrates + Alfuzosin Hydrochloride— Increased risk of hypotension, postural hypotension, and syncope when used concomitantly with alfuzosin.
- Nitrates + Dapsone— Concomitant use may increase risk of methemoglobinemia.
- Nitrates + Epinephrine— Vasodilator that antagonizes pressor effects of epinephrine.
Moderate (9)
- Nitrates + Bupivacaine Hydrochloride— Increased risk of methemoglobinemia when concurrently exposed to nitrates.
- Nitrates + Captopril— Data on concomitant use with captopril for heart failure are not available. Should be discontinued before starting capto…
- Nitrates + Captopril And Hydrochlorothiazide— Other nitrates used for angina management should be discontinued before captopril initiation; if resumed, use cautiously…
- Nitrates + Dicyclomine Hydrochloride— May increase certain actions or side effects of anticholinergic drugs including dicyclomine hydrochloride.
- Nitrates + Epinephrine In Sodium Chloride— Vasodilator that counters the pressor effects of epinephrine.
- Nitrates + Lidocaine Hydrochloride— Patients at increased risk of developing methemoglobinemia when concurrently exposed to nitrates and lidocaine.
- Nitrates + Lidocaine Hydrochloride And Epinephrine Bitartrate— Increased risk of developing methemoglobinemia when concurrently exposed.
- Nitrates + Methylprednisolone Acetate, Lidocaine Hydrochloride, Bupivacaine Hydrochloride, Povidine Iodine, Sodium Chloride, Isopropyl Alcohol— Increased risk of methemoglobinemia when concurrently exposed.
- Nitrates + Nifedipine— Nifedipine may be safely co-administered with long-acting nitrates, but no controlled studies have evaluated antianginal…
Minor (3)
- Nitrates + Enalapril Maleate— Used concomitantly with enalapril maleate without evidence of clinically significant adverse interactions.
- Nitrates + Enalapril Maleate And Hydrochlorothiazide— Enalapril has been used concomitantly without evidence of clinically significant adverse interactions.
- Nitrates + Lisinopril And Hydrochlorothiazide Tablets— Lisinopril has been used concomitantly with nitrates without evidence of clinically significant adverse interactions.