Does Nitrates Interact with Macitentan And Tadalafil?
Nitrates and Macitentan And Tadalafil have a contraindicated drug interaction according to U.S. FDA drug labeling data. Administration of nitrates within 48 hours after the last dose of OPSYNVI is contraindicated. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Contraindicated
- Macitentan And Tadalafil Class
- Endothelin Receptor Antagonist
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Nitrates and your doctor is considering prescribing Macitentan And Tadalafil (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider