Does Sildenafil Interact with Nitrates?
Contraindicated interaction. Administration of sildenafil with nitrates is contraindicated. Sildenafil potentiates the hypotensive effects of nitrates.
Source & how this summary was prepared
This interaction summary was extracted from FDA drug labeling through openFDA, using automated processing and AI assistance. NIH/NLM RxNorm helps organize drug names.
Read the saved source label on DailyMed →
A separate current-label comparison has not been recorded for this page. Read about our extraction process.
- Interaction classification
- Contraindicated
- Sildenafil Class
- Phosphodiesterase 5 Inhibitor
- Management
- Confirm exact products with your pharmacist
- Data Source
- U.S. FDA via OpenFDA
How this interaction works
Effects on nitric oxide/cGMP pathway
What To Tell Your Doctor or Pharmacist
If you are taking Sildenafil and your doctor is considering prescribing Nitrates (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider