Nitrates + Sildenafil Citrate Interaction
Contraindicatedinteraction on record
Description
Administration of sildenafil with nitrates is contraindicated. Sildenafil potentiates the hypotensive effects of nitrates through effects on the nitric oxide/cGMP pathway.
Mechanism
Potentiation of nitric oxide/cGMP pathway effects on blood pressure
Source: NLP:sildenafil citrate