Does Velpatasvir And Sofosbuvir Interact with Rosuvastatin Calcium?
Velpatasvir And Sofosbuvir and Rosuvastatin Calcium have a major drug interaction according to U.S. FDA drug labeling data. Increases rosuvastatin exposure. Limit rosuvastatin dose to 10 mg once daily. The mechanism involves increased rosuvastatin exposure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Velpatasvir And Sofosbuvir Class
- Hepatitis C Virus Nucleotide Analog NS5B Polymerase Inhibitor
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Velpatasvir And Sofosbuvir and Rosuvastatin Calcium occurs because increased rosuvastatin exposure. Clinically, this means increases rosuvastatin exposure. limit rosuvastatin dose to 10 mg once daily. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Velpatasvir And Sofosbuvir and your doctor is considering prescribing Rosuvastatin Calcium (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider