Does Warfarin Interact with Velpatasvir And Sofosbuvir?
Warfarin and Velpatasvir And Sofosbuvir have a moderate drug interaction according to U.S. FDA drug labeling data. Frequent monitoring of INR and dose adjustments may be necessary due to HCV clearance-related changes in hepatic function. The mechanism involves altered hepatic function following hcv infection clearance. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Velpatasvir And Sofosbuvir Class
- Hepatitis C Virus Nucleotide Analog NS5B Polymerase Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Warfarin and Velpatasvir And Sofosbuvir occurs because altered hepatic function following hcv infection clearance. Clinically, this means frequent monitoring of inr and dose adjustments may be necessary due to hcv clearance-related changes in hepatic function. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Warfarin and your doctor is considering prescribing Velpatasvir And Sofosbuvir (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider