Does Velpatasvir And Sofosbuvir Interact with Rifampin?
Velpatasvir And Sofosbuvir and Rifampin have a major drug interaction according to U.S. FDA drug labeling data. P-gp and moderate to strong CYP inducer that may decrease concentrations of sofosbuvir and/or velpatasvir, leading to reduced therapeutic effect. Use not recommended. The mechanism involves induction of p-gp and cyp2b6, cyp2c8, or cyp3a4. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Velpatasvir And Sofosbuvir Class
- Hepatitis C Virus Nucleotide Analog NS5B Polymerase Inhibitor
- Rifampin Class
- Rifamycin Antibacterial
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Velpatasvir And Sofosbuvir and Rifampin occurs because induction of p-gp and cyp2b6, cyp2c8, or cyp3a4. Clinically, this means p-gp and moderate to strong cyp inducer that may decrease concentrations of sofosbuvir and/or velpatasvir, leading to reduced therapeutic effect. use not recommended. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Velpatasvir And Sofosbuvir and your doctor is considering prescribing Rifampin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider