Macitentan And Tadalafil has 14 known drug interactions based on U.S. FDA drug labeling data. Of these, 6 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Amiodarone, Fluconazole, Itraconazole. Patients taking Macitentan And Tadalafil should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 14
- Contraindicated
- 6
- Major
- 2
- Moderate
- 6
Contraindicated (6)
- Macitentan And Tadalafil + Amiodarone— Moderate dual CYP3A4 and CYP2C9 inhibitor increases macitentan exposure. Avoid concomitant use.
- Macitentan And Tadalafil + Fluconazole— Moderate dual CYP3A4 and CYP2C9 inhibitor predicted to increase macitentan exposure approximately 4-fold. Avoid concomit…
- Macitentan And Tadalafil + Itraconazole— Strong CYP3A4 inhibitor that increases exposure to both macitentan and tadalafil. Avoid concomitant use.
- Macitentan And Tadalafil + Ketoconazole— Strong CYP3A4 inhibitor that increases exposure to both macitentan and tadalafil. Avoid concomitant use.
- Macitentan And Tadalafil + Nitrates— Administration of nitrates within 48 hours after the last dose of OPSYNVI is contraindicated.
- Macitentan And Tadalafil + Ritonavir— Strong CYP3A4 inhibitor that increases exposure to both macitentan and tadalafil. Avoid concomitant use.
Major (2)
- Macitentan And Tadalafil + Doxazosin— Alpha-1 blocker; concomitant administration may lead to symptomatic hypotension. Combination is not recommended.
- Macitentan And Tadalafil + Rifampin— Strong CYP3A4 inducer that significantly reduces macitentan exposure. Concomitant use should be avoided.
Moderate (6)
- Macitentan And Tadalafil + Alcohol— Substantial consumption (5+ units) combined with OPSYNVI increases potential for orthostatic signs and symptoms includin…
- Macitentan And Tadalafil + Amlodipine— Antihypertensive; small reductions in blood pressure occur following coadministration with tadalafil.
- Macitentan And Tadalafil + Angiotensin Ii— Antihypertensives; small reductions in blood pressure occur following coadministration with tadalafil.
- Macitentan And Tadalafil + Bendroflumethiazide— Antihypertensive; small reductions in blood pressure occur following coadministration with tadalafil.
- Macitentan And Tadalafil + Enalapril— Antihypertensive; small reductions in blood pressure occur following coadministration with tadalafil.
- Macitentan And Tadalafil + Metoprolol— Antihypertensive; small reductions in blood pressure occur following coadministration with tadalafil.