Macitentan And Tadalafil + Ketoconazole Interaction
Majorinteraction on record
Description
7.3 Strong CYP3A4 Inhibitors Concomitant use of strong CYP3A4 inhibitors like ketoconazole increase exposure to both macitentan and tadalafil. Avoid concomitant use of OPSYNVI with strong CYP3A4 inhibitors such as ritonavir, ketoconazole and itraconazole.
Source: FDA drug label - macitentan and tadalafil