Home›Macitentan And Tadalafil›Macitentan And Tadalafil + Fluconazole

Does Macitentan And Tadalafil Interact with Fluconazole?

Macitentan And Tadalafil and Fluconazole have a contraindicated drug interaction according to U.S. FDA drug labeling data. Moderate dual CYP3A4 and CYP2C9 inhibitor predicted to increase macitentan exposure approximately 4-fold. Avoid concomitant use. The mechanism involves cyp3a4 and cyp2c9 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Macitentan And Tadalafil Class
Endothelin Receptor Antagonist
Fluconazole Class
Azole Antifungal
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Macitentan And Tadalafil and Fluconazole occurs because cyp3a4 and cyp2c9 inhibition. Clinically, this means moderate dual cyp3a4 and cyp2c9 inhibitor predicted to increase macitentan exposure approximately 4-fold. avoid concomitant use. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Macitentan And Tadalafil and your doctor is considering prescribing Fluconazole (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Macitentan And Tadalafil(Opsynvi)+💊 Fluconazole

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Endothelin Receptor Antagonist
Drug B class
Azole Antifungal
Source
NLP:macitentan and tadalafil

What this means in plain English

Moderate dual CYP3A4 and CYP2C9 inhibitor predicted to increase macitentan exposure approximately 4-fold. Avoid concomitant use.

What the FDA label says

"CYP3A4 and CYP2C9 inhibition"

📖 Source: NLP:macitentan and tadalafil

Share this result:

WhatsAppText / SMSEmail
Also share on:XFacebook
Add more drugs
Check Macitentan And Tadalafil and Fluconazole against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.