Bisoprolol Fumarate And Hydrochlorothiazide

Should not be combined with other beta-blocking agents due to additive effects.

Bisoprolol should be discontinued several days before clonidine withdrawal to avoid rebound hypertension and excessive sympathetic reduction.

Both digitalis and beta-blockers slow AV conduction and decrease heart rate. Concomitant use increases risk of bradycardia.

Catecholamine-depleting drug that with bisoprolol's beta-adrenergic blocking action may produce excessive reduction of sympathetic activity. Close monitoring required.

Catecholamine-depleting drug that with bisoprolol's beta-adrenergic blocking action may produce excessive reduction of sympathetic activity. Close monitoring required.

Calcium antagonist that may depress myocardium and inhibit AV conduction. Use with caution when combined with bisoprolol.

Bisoprolol fumarate and hydrochlorothiazide tablets should be used with caution when myocardial depressants or inhibitors of AV conduction, such as certain calcium antagonists (particularly of the phenylalkylamine [verapamil] and benzothiazepine [diltiazem] classes), or antiarrhythmic agents, such as disopyramide, are used concurrently.

Calcium antagonist that may depress myocardium and inhibit AV conduction. Use with caution when combined with bisoprolol.

Drug Interactions Bisoprolol fumarate and hydrochlorothiazide tablets may potentiate the action of other antihypertensive agents used concomitantly. Bisoprolol fumarate and hydrochlorothiazide tablets should not be combined with other beta-blocking agents. Patients receiving catecholamine-depleting drugs, such as reserpine or guanethidine, should be closely monitored because the added beta-adrenergic blocking action of bisoprolol fumarate may produce excessive reduction of sympathetic activity.

Drug Interactions Bisoprolol fumarate and hydrochlorothiazide tablets may potentiate the action of other antihypertensive agents used concomitantly. Bisoprolol fumarate and hydrochlorothiazide tablets should not be combined with other beta-blocking agents. In patients receiving concurrent therapy with clonidine, if therapy is to be discontinued, it is suggested that bisoprolol fumarate and hydrochlorothiazide tablets be discontinued for several days before the withdrawal of clonidine.