Didanosine Interactions

Coadministration increases didanosine exposure and active metabolite, causing or worsening clinical toxicities including fatal hepatic failure, peripheral neuropathy, pancreatitis, and symptomatic hyperlactatemia/lactic acidosis.

Source: NLP:ribavirin

Co-administration is contraindicated based on FDA labeling.

Source: NLP:rifabutin

Tenofovir disoproxil fumarate increases didanosine concentrations. Close monitoring for didanosine toxicity is warranted; dose reduction recommended for patients >60 kg.

Source: NLP:emtricitabine and tenofovir disoproxil fumarate

Increased didanosine concentrations. Patients should be closely monitored for didanosine toxicity including pancreatitis.

Source: NLP:ganciclovir sodium

Fatal and nonfatal pancreatitis has occurred in HIV patients receiving hydroxyurea with didanosine, with or without stavudine. Close monitoring for pancreatitis signs/symptoms is recommended.

Source: NLP:hydroxyurea

Tenofovir disoproxil fumarate increases didanosine concentrations, potentiating didanosine-associated adverse reactions including pancreatitis and neuropathy. Dose reduction required.

Source: NLP:tenofovir disoproxil fumarate

Coadministration with buffered formulations decreases atazanavir and didanosine concentrations. Atazanavir should be given 2 hours before or 1 hour after didanosine buffered formulations, or at different times with enteric-coated capsules.

Source: NLP:atazanavir

Co-administration may alter concentrations of both drugs. Didanosine should be administered one hour before or two hours after darunavir/ritonavir.

Source: NLP:darunavir

Didanosine formulations containing divalent and trivalent cations form chelates with delafloxacin, substantially interfering with absorption and resulting in considerably lower systemic concentrations.

Source: NLP:delafloxacin meglumine

Ganciclovir may increase didanosine concentrations. Monitor closely for didanosine toxicity including pancreatitis.

Source: NLP:ganciclovir

Absorption of levofloxacin is decreased when tablets are taken within 2 hours of didanosine, resulting in considerably lower systemic levels.

Source: NLP:levofloxacin

Divalent and trivalent cations may substantially interfere with moxifloxacin absorption. Take moxifloxacin at least 4 hours before or 8 hours after didanosine.

Source: NLP:moxifloxacin hydrochloride

Didanosine formulations substantially interfere with ofloxacin absorption, resulting in considerably lower systemic levels. Should not be taken within 2 hours before or after ofloxacin.

Source: NLP:ofloxacin

Valganciclovir may increase didanosine concentrations. Patients should be closely monitored for didanosine toxicity.

Source: NLP:valganciclovir

May increase didanosine concentration. Patients should be closely monitored for didanosine toxicity including pancreatitis.

Source: NLP:valganciclovir hydrochloride