Didanosine + Ribavirin Interaction
Contraindicatedinteraction on record
Description
Coadministration increases didanosine exposure and active metabolite, causing or worsening clinical toxicities including fatal hepatic failure, peripheral neuropathy, pancreatitis, and symptomatic hyperlactatemia/lactic acidosis.
Mechanism
Increased exposure to didanosine and its active metabolite (dideoxyadenosine 5'-triphosphate)
Source: NLP:ribavirin