Does Didanosine Interact with Levofloxacin?
CDI records a contraindicated classification for Didanosine and Levofloxacin. The stored summary is: Do not co-administer intravenous levofloxacin in the same IV line with didanosine due to chelation with multivalent cations. The mechanism involves chelation interaction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Levofloxacin Class
- Fluoroquinolone Antibacterial
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Chelation interaction
What To Tell Your Doctor or Pharmacist
If you are taking Didanosine and your doctor is considering prescribing Levofloxacin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider