Does Epinephrine Interact with Propranolol Hydrochloride?
CDI records a contraindicated classification for Epinephrine and Propranolol Hydrochloride. The stored summary is: Patients on long-term propranolol therapy may experience uncontrolled hypertension if administered epinephrine due to unopposed alpha-receptor stimulation. Not indicated for propranolol overdose. The mechanism involves unopposed alpha-receptor stimulation. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Epinephrine Class
- alpha-Adrenergic Agonist
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Unopposed alpha-receptor stimulation
What To Tell Your Doctor or Pharmacist
If you are taking Epinephrine and your doctor is considering prescribing Propranolol Hydrochloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider