Does Chlorothiazide Sodium Interact with Nonsteroidal Anti Inflammatory Drugs Nsaids?
Chlorothiazide Sodium and Nonsteroidal Anti Inflammatory Drugs Nsaids have a moderate drug interaction according to U.S. FDA drug labeling data. NSAIDs can reduce the diuretic, natriuretic, and antihypertensive effects of chlorothiazide sodium. Patient should be closely observed to determine if desired diuretic effect is obtained. The mechanism involves antagonism of diuretic and antihypertensive effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Chlorothiazide Sodium and Nonsteroidal Anti Inflammatory Drugs Nsaids occurs because antagonism of diuretic and antihypertensive effects. Clinically, this means nsaids can reduce the diuretic, natriuretic, and antihypertensive effects of chlorothiazide sodium. patient should be closely observed to determine if desired diuretic effect is obtained. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Chlorothiazide Sodium and your doctor is considering prescribing Nonsteroidal Anti Inflammatory Drugs Nsaids (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider