Does Chlorothiazide Sodium Interact with Repository Corticotropin?
Chlorothiazide Sodium and Repository Corticotropin have a major drug interaction according to U.S. FDA drug labeling data. Intensified electrolyte depletion, particularly hypokalemia, may occur when ACTH is given with chlorothiazide sodium. The mechanism involves enhanced electrolyte depletion. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Repository Corticotropin Class
- Adrenocorticotropic Hormone
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Chlorothiazide Sodium and Repository Corticotropin occurs because enhanced electrolyte depletion. Clinically, this means intensified electrolyte depletion, particularly hypokalemia, may occur when acth is given with chlorothiazide sodium. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Chlorothiazide Sodium and your doctor is considering prescribing Repository Corticotropin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider