Does Abacavir Sulfate Dolutegravir Sodium Lamivudine Interact with Etravirine?
Abacavir Sulfate Dolutegravir Sodium Lamivudine and Etravirine have a major drug interaction according to U.S. FDA drug labeling data. Etravirine significantly reduced plasma concentrations of dolutegravir, potentially reducing therapeutic effect. Effect may be mitigated by coadministration with lopinavir/ritonavir or darunavir/ritonavir. The mechanism involves induction of ugt1a1 and/or cyp3a enzymes. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Abacavir Sulfate Dolutegravir Sodium Lamivudine Class
- Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor
- Etravirine Class
- Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Abacavir Sulfate Dolutegravir Sodium Lamivudine and Etravirine occurs because induction of ugt1a1 and/or cyp3a enzymes. Clinically, this means etravirine significantly reduced plasma concentrations of dolutegravir, potentially reducing therapeutic effect. effect may be mitigated by coadministration with lopinavir/ritonavir or darunavir/ritonavir. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Abacavir Sulfate Dolutegravir Sodium Lamivudine and your doctor is considering prescribing Etravirine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider