Does Abacavir Sulfate Dolutegravir Sodium Lamivudine Interact with Midazolam?
Abacavir Sulfate Dolutegravir Sodium Lamivudine and Midazolam have a unknown drug interaction according to U.S. FDA drug labeling data. In drug interaction trials, dolutegravir did not have a clinically relevant effect on the pharmacokinetics of the following drugs: tenofovir, methadone, midazolam, rilpivirine, and oral contraceptives containing norgestimate and ethinyl estradiol. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Unknown
- Abacavir Sulfate Dolutegravir Sodium Lamivudine Class
- Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor
- Midazolam Class
- Benzodiazepine
- Management
- Consult your pharmacist
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Abacavir Sulfate Dolutegravir Sodium Lamivudine and your doctor is considering prescribing Midazolam (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider