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Does Aliskiren Interact with Azilsartan Kamedoxomil?

Aliskiren and Azilsartan Kamedoxomil have a contraindicated drug interaction according to U.S. FDA drug labeling data. Contraindicated with azilsartan in patients with diabetes. Avoid in patients with renal impairment (GFR <60 mL/min). Dual RAS blockade increases risk of hypotension, hyperkalemia, and acute renal failure. The mechanism involves dual blockade of renin-angiotensin system. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Azilsartan Kamedoxomil Class
Thiazide-like Diuretic
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Aliskiren and Azilsartan Kamedoxomil occurs because dual blockade of renin-angiotensin system. Clinically, this means contraindicated with azilsartan in patients with diabetes. avoid in patients with renal impairment (gfr <60 ml/min). dual ras blockade increases risk of hypotension, hyperkalemia, and acute renal failure. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Aliskiren and your doctor is considering prescribing Azilsartan Kamedoxomil (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Aliskiren(Tekturna HCT)+💊 Azilsartan Kamedoxomil(Azilsartan Medoxomil)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Thiazide-like Diuretic
Source
NLP:azilsartan kamedoxomil and chlorthalidone

What this means in plain English

Contraindicated with azilsartan in patients with diabetes. Avoid in patients with renal impairment (GFR <60 mL/min). Dual RAS blockade increases risk of hypotension, hyperkalemia, and acute renal failure.

About Aliskiren and Azilsartan Kamedoxomil

Azilsartan Kamedoxomil is a Thiazide-like Diuretic. Aliskiren is also sold under the brand name Tekturna HCT. Both medications are taken by mouth. Both Aliskiren and Azilsartan Kamedoxomil carry an FDA boxed warning — the agency's most serious safety designation.

What the FDA label says

"Dual blockade of renin-angiotensin system"

📖 Source: NLP:azilsartan kamedoxomil and chlorthalidone

Recent research & FDA safety updates

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Auto-aggregated from PubMed E-utilities and FDA safety data.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.