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Does Aliskiren Interact with Benazepril Hydrochloride And Hydrochlorothiazide?

Aliskiren and Benazepril Hydrochloride And Hydrochlorothiazide have a contraindicated drug interaction according to U.S. FDA drug labeling data. Do not coadminister with benazepril/hydrochlorothiazide in patients with diabetes. Avoid in renal impairment (GFR < 60 mL/min) due to increased risks of hyperkalemia and acute renal failure. The mechanism involves dual ras blockade. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Benazepril Hydrochloride And Hydrochlorothiazide Class
Thiazide Diuretic
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Aliskiren and Benazepril Hydrochloride And Hydrochlorothiazide occurs because dual ras blockade. Clinically, this means do not coadminister with benazepril/hydrochlorothiazide in patients with diabetes. avoid in renal impairment (gfr < 60 ml/min) due to increased risks of hyperkalemia and acute renal failure. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Aliskiren and your doctor is considering prescribing Benazepril Hydrochloride And Hydrochlorothiazide (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Aliskiren(Aliskiren)+💊 Benazepril Hydrochloride And Hydrochlorothiazide(Lotensin Hct)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Thiazide Diuretic
Source
NLP:benazepril hydrochloride and hydrochlorothiazide

What this means in plain English

Do not coadminister with benazepril/hydrochlorothiazide in patients with diabetes. Avoid in renal impairment (GFR < 60 mL/min) due to increased risks of hyperkalemia and acute renal failure.

What the FDA label says

"Dual RAS blockade"

📖 Source: NLP:benazepril hydrochloride and hydrochlorothiazide

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.