Does Aliskiren Interact with Olmesartan Medoxomil Hydrochlorothiazide?
CDI records a contraindicated classification for Aliskiren and Olmesartan Medoxomil Hydrochlorothiazide. The stored summary is: Do not co-administer aliskiren with BENICAR HCT in patients with diabetes. Avoid use in patients with renal impairment (GFR <60 ml/min) due to increased risks of hypotension, hyperkalemia, and renal failure. The mechanism involves dual ras inhibition leads to excessive suppression of the renin-angiotensin system. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Olmesartan Medoxomil Hydrochlorothiazide Class
- Thiazide Diuretic
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Dual RAS inhibition leads to excessive suppression of the renin-angiotensin system
What To Tell Your Doctor or Pharmacist
If you are taking Aliskiren and your doctor is considering prescribing Olmesartan Medoxomil Hydrochlorothiazide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider