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Does Aliskiren Interact with Olmesartan Medoxomil Hydrochlorothiazide?

Aliskiren and Olmesartan Medoxomil Hydrochlorothiazide have a contraindicated drug interaction according to U.S. FDA drug labeling data. Do not co-administer aliskiren with BENICAR HCT in patients with diabetes. Avoid use in patients with renal impairment (GFR <60 ml/min) due to increased risks of hypotension, hyperkalemia, and renal failure. The mechanism involves dual ras inhibition leads to excessive suppression of the renin-angiotensin system. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Olmesartan Medoxomil Hydrochlorothiazide Class
Thiazide Diuretic
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Aliskiren and Olmesartan Medoxomil Hydrochlorothiazide occurs because dual ras inhibition leads to excessive suppression of the renin-angiotensin system. Clinically, this means do not co-administer aliskiren with benicar hct in patients with diabetes. avoid use in patients with renal impairment (gfr <60 ml/min) due to increased risks of hypotension, hyperkalemia, and renal failure. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Aliskiren and your doctor is considering prescribing Olmesartan Medoxomil Hydrochlorothiazide (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Aliskiren(Aliskiren)+💊 Olmesartan Medoxomil Hydrochlorothiazide(Benicar Hct)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Thiazide Diuretic
Source
NLP:olmesartan medoxomil-hydrochlorothiazide

What this means in plain English

Do not co-administer aliskiren with BENICAR HCT in patients with diabetes. Avoid use in patients with renal impairment (GFR <60 ml/min) due to increased risks of hypotension, hyperkalemia, and renal failure.

What the FDA label says

"Dual RAS inhibition leads to excessive suppression of the renin-angiotensin system"

📖 Source: NLP:olmesartan medoxomil-hydrochlorothiazide

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.