Does Aspirin Interact with Carisoprodol?
Aspirin and Carisoprodol have a moderate drug interaction according to U.S. FDA drug labeling data. Low dose aspirin showed induction effect on CYP2C19, potentially decreasing carisoprodol exposure and increasing meprobamate exposure; full pharmacological impact unknown. The mechanism involves cyp2c19 induction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Aspirin Class
- Nonsteroidal Anti-inflammatory Drug [EPC]
- Carisoprodol Class
- Muscle Relaxant
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Aspirin and Carisoprodol occurs because cyp2c19 induction. Clinically, this means low dose aspirin showed induction effect on cyp2c19, potentially decreasing carisoprodol exposure and increasing meprobamate exposure; full pharmacological impact unknown. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Aspirin and your doctor is considering prescribing Carisoprodol (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider