Does Aspirin Interact with Prednisone?
CDI records a moderate classification for Aspirin and Prednisone. The stored summary is: Prednisone may increase clearance of high-dose chronic aspirin, leading to decreased salicylate levels or increased toxicity upon withdrawal. Use cautiously in hypoprothrombinemia. The mechanism involves increased clearance of aspirin. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Aspirin Class
- Nonsteroidal Anti-inflammatory Drug [EPC]
- Prednisone Class
- Corticosteroid
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Increased clearance of aspirin
What To Tell Your Doctor or Pharmacist
If you are taking Aspirin and your doctor is considering prescribing Prednisone (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider