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Does Atazanavir And Cobicistat Interact with Efavirenz Emtricitabine And Tenofovir Disoproxil Fumarate?

Atazanavir And Cobicistat and Efavirenz Emtricitabine And Tenofovir Disoproxil Fumarate have a contraindicated drug interaction according to U.S. FDA drug labeling data. Coadministration is not recommended. Combined effect on atazanavir plasma concentrations uncertain. The mechanism involves efavirenz induction of cyp3a. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Atazanavir And Cobicistat Class
Cytochrome P450 3A Inhibitor
Efavirenz Emtricitabine And Tenofovir Disoproxil Fumarate Class
Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Atazanavir And Cobicistat and Efavirenz Emtricitabine And Tenofovir Disoproxil Fumarate occurs because efavirenz induction of cyp3a. Clinically, this means coadministration is not recommended. combined effect on atazanavir plasma concentrations uncertain. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Atazanavir And Cobicistat and your doctor is considering prescribing Efavirenz Emtricitabine And Tenofovir Disoproxil Fumarate (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Atazanavir And Cobicistat(Evotaz)+💊 Efavirenz Emtricitabine And Tenofovir Disoproxil Fumarate(Efavirenz, Emtricitabine And Tenofovir Disoproxil Fumarate)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Cytochrome P450 3A Inhibitor
Drug B class
Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor
Source
NLP:efavirenz, emtricitabine and tenofovir disoproxil fumarate

What this means in plain English

Coadministration is not recommended. Combined effect on atazanavir plasma concentrations uncertain.

What the FDA label says

"Efavirenz induction of CYP3A"

📖 Source: NLP:efavirenz, emtricitabine and tenofovir disoproxil fumarate

Recent research & FDA safety updates

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Auto-aggregated from PubMed E-utilities and FDA safety data.

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.