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Does Atazanavir And Cobicistat Interact with Repaglinide?

Atazanavir And Cobicistat and Repaglinide have a major drug interaction according to U.S. FDA drug labeling data. Repaglinide is highly dependent on CYP2C8 for clearance with narrow therapeutic index. EVOTAZ use is not recommended with repaglinide due to potential for increased plasma concentrations. The mechanism involves cyp2c8 inhibition by atazanavir. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Atazanavir And Cobicistat Class
Cytochrome P450 3A Inhibitor
Repaglinide Class
Glinide
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Atazanavir And Cobicistat and Repaglinide occurs because cyp2c8 inhibition by atazanavir. Clinically, this means repaglinide is highly dependent on cyp2c8 for clearance with narrow therapeutic index. evotaz use is not recommended with repaglinide due to potential for increased plasma concentrations. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Atazanavir And Cobicistat and your doctor is considering prescribing Repaglinide (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Atazanavir And Cobicistat(Evotaz)+💊 Repaglinide(Repaglinide)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Cytochrome P450 3A Inhibitor
Drug B class
Glinide
Source
NLP:atazanavir and cobicistat

What this means in plain English

Repaglinide is highly dependent on CYP2C8 for clearance with narrow therapeutic index. EVOTAZ use is not recommended with repaglinide due to potential for increased plasma concentrations.

What the FDA label says

"CYP2C8 inhibition by atazanavir"

📖 Source: NLP:atazanavir and cobicistat

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.