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Does Bacillus Calmette Guerin Interact with Isoniazid?

Bacillus Calmette Guerin and Isoniazid have a contraindicated drug interaction according to U.S. FDA drug labeling data. Antituberculosis drugs should not be used to prevent or treat local irritative toxicities of TICE BCG, as these are not due to mycobacterial infection. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Bacillus Calmette Guerin Class
Live Attenuated Bacillus Calmette-Guerin Vaccine
Isoniazid Class
Antimycobacterial
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Bacillus Calmette Guerin and your doctor is considering prescribing Isoniazid (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Bacillus Calmette Guerin(Tice Bcg)+💊 Isoniazid(Isoniazid)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Live Attenuated Bacillus Calmette-Guerin Vaccine
Drug B class
Antimycobacterial
Source
NLP:bacillus calmette-guerin

What this means in plain English

Antituberculosis drugs should not be used to prevent or treat local irritative toxicities of TICE BCG, as these are not due to mycobacterial infection.

About Bacillus Calmette Guerin and Isoniazid

Bacillus Calmette Guerin is a Live Attenuated Bacillus Calmette-Guerin Vaccine, while Isoniazid is an Antimycobacterial. Bacillus Calmette Guerin is also sold under the brand name Tice Bcg. Bacillus Calmette Guerin is given by the intravesical route, whereas Isoniazid is taken by mouth. Both Bacillus Calmette Guerin and Isoniazid carry an FDA boxed warning — the agency's most serious safety designation.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.