Does Carbamazepine Interact with Isoniazid?
CDI records a major classification for Carbamazepine and Isoniazid. The stored summary is: Isoniazid slows metabolism and increases serum levels of carbamazepine, requiring monitoring for toxicity signs and dosage adjustment. The mechanism involves decreased carbamazepine metabolism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Carbamazepine Class
- Mood Stabilizer
- Isoniazid Class
- Antimycobacterial
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Decreased carbamazepine metabolism
What To Tell Your Doctor or Pharmacist
If you are taking Carbamazepine and your doctor is considering prescribing Isoniazid (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider