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Does Cefotaxime Interact with Probenecid?

Cefotaxime and Probenecid have a moderate drug interaction according to U.S. FDA drug labeling data. Probenecid decreases renal tubular transfer of cefotaxime, reducing total clearance by approximately 50% and increasing plasma concentrations by approximately 80%. Avoid cefotaxime doses exceeding 6 grams/day in patients receiving probenecid. The mechanism involves interference with renal tubular transfer of cefotaxime. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Cefotaxime and Probenecid occurs because interference with renal tubular transfer of cefotaxime. Clinically, this means probenecid decreases renal tubular transfer of cefotaxime, reducing total clearance by approximately 50% and increasing plasma concentrations by approximately 80%. avoid cefotaxime doses exceeding 6 grams/day in patients receiving probenecid. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.

What To Tell Your Doctor or Pharmacist

If you are taking Cefotaxime and your doctor is considering prescribing Probenecid (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Cefotaxime(Cefotaxime)+💊 Probenecid(Probenecid)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
NLP:cefotaxime

What this means in plain English

Probenecid decreases renal tubular transfer of cefotaxime, reducing total clearance by approximately 50% and increasing plasma concentrations by approximately 80%. Avoid cefotaxime doses exceeding 6 grams/day in patients receiving probenecid.

What the FDA label says

"Interference with renal tubular transfer of cefotaxime"

📖 Source: NLP:cefotaxime

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.