Does Cholestyramine Light Interact with Ezetimibe?
CDI records a moderate classification for Cholestyramine Light and Ezetimibe. The stored summary is: Cholestyramine decreases mean exposure of total ezetimibe, resulting in reduced efficacy. Administer ezetimibe at least 2 hours before or 4 hours after cholestyramine. The mechanism involves decreased ezetimibe exposure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Cholestyramine Light Class
- Bile Acid Sequestrant
- Ezetimibe Class
- Dietary Cholesterol Absorption Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Decreased ezetimibe exposure
What To Tell Your Doctor or Pharmacist
If you are taking Cholestyramine Light and your doctor is considering prescribing Ezetimibe (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider