Does Fibrates Interact with Ezetimibe?
CDI records a contraindicated classification for Fibrates and Ezetimibe. The stored summary is: Co-administration of ezetimibe with fibrates other than fenofibrate is not recommended until adequately studied. The mechanism involves both increase cholesterol excretion into bile, leading to cholelithiasis. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Ezetimibe Class
- Dietary Cholesterol Absorption Inhibitor
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Both increase cholesterol excretion into bile, leading to cholelithiasis
What To Tell Your Doctor or Pharmacist
If you are taking Fibrates and your doctor is considering prescribing Ezetimibe (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider