Does Cyclophosphamide Interact with Cyclophosphamide For Injection?
Cyclophosphamide and Cyclophosphamide For Injection have a moderate drug interaction according to U.S. FDA drug labeling data. DRUG INTERACTIONS 7.1 Effect of Other Drugs on Cyclophosphamide Exposure Protease Inhibitors Concomitant use of protease inhibitors may increase the concentration of cytotoxic metabolites and may enhance the toxicities of cyclophosphamide, including higher incidence of infections, neutropenia, and mucositis. 7.2 Drugs That Potentiate Cyclophosphamide Toxicities Radiation therapy or drugs with similar toxicities to Cyclophosphamide for Injection can potentiate toxicities for cyclophosphamide. Monitor for increased toxicities in patients receiving radiation therapy or drugs known to cause: • Myelosuppression and/or immunosuppression [ see Warnings and Precautions ( 5.1 ) ] • Nephrotoxicity including hemorrhagic cystitis [ see Warnings and Precautions ( 5.2 ) ] • Cardiotoxicity [ see Warnings and Precautions ( 5.3 ) ] • Pulmonary toxicity [ see Warnings and Precautions ( 5.4 ) ] • Secondary malignancies [ see Warnings and Precautions ( 5.5 ) ] • Hepatotoxicity including liver necrosis and VOD [ see Warnings and Precautions ( 5.6 ) ] 7.3 Effect of Cyclophosphamide on Other Drugs Metronidazole Acute encephalopathy has been reported in a patient receiving cyclophosphamide and metronidazole. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Cyclophosphamide Class
- Alkylating Drug
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Cyclophosphamide and your doctor is considering prescribing Cyclophosphamide For Injection (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider