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Does Cyclophosphamide For Injection Interact with Protease Inhibitors?

Cyclophosphamide For Injection and Protease Inhibitors have a major drug interaction according to U.S. FDA drug labeling data. Concomitant use may increase concentration of cytotoxic metabolites and enhance toxicities of cyclophosphamide, including higher incidence of infections, neutropenia, and mucositis. The mechanism involves increased concentration of cytotoxic metabolites. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Cyclophosphamide For Injection and Protease Inhibitors occurs because increased concentration of cytotoxic metabolites. Clinically, this means concomitant use may increase concentration of cytotoxic metabolites and enhance toxicities of cyclophosphamide, including higher incidence of infections, neutropenia, and mucositis. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Cyclophosphamide For Injection and your doctor is considering prescribing Protease Inhibitors (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Cyclophosphamide For Injection(Cyclophosphamide)+💊 Protease Inhibitors

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
NLP:cyclophosphamide for injection

What this means in plain English

Concomitant use may increase concentration of cytotoxic metabolites and enhance toxicities of cyclophosphamide, including higher incidence of infections, neutropenia, and mucositis.

What the FDA label says

"Increased concentration of cytotoxic metabolites"

📖 Source: NLP:cyclophosphamide for injection

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.